Breakfast Breakout Roundtable Discussions

WEDNESDAY, JUNE 19 | 8:00-8:55 AM

These are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic.

Modulation of Trained Immunity in Disease: from Bench to Bedside

Moderator: Mihai Netea, Radboud University Medical Center, Nijmegen, the Netherlands

  • Trained immunity modulation: target diseases and approaches
  • Pathophysiology of excessive inflammation: role of trained immunity
  • Inhibitory strategies
  • Targeting trained immunity and macrophage reprogramming in cancer
  • Optimized myeloid cell-specific delivery

Clinical Development of CAR – NK Cells – Challenges and Opportunities

Moderator: Torsten Tonn, MD, PhD, Group Leader, Research Laboratory Experimental Transfusion Medicine; Professor, Transfusion Medicine, Medical Faculty Carl-Gustav-Carus, Technische Universität Dresden, Germany

  • Relative resistance of NK cells to genetic manipulation (compared to T cells)
  • How can we overcome the limitation in the in vitro and in vivo expansion capacity of NK cells
  • How do the future CAR´s should look like for NK cell based therapies (inducible in vivo expansion, tonic signalling, universal CARs / CAR-PARK)

Targeting Dendritic Cells to Enhance T Cells Responses in Cancer

Moderator: Sonia Feau, PhD, Associate Director, Immunology, Oncorus

  • Challenges and success of the different approaches: cell therapy, PAMPs agonists, vaccination
  • How to specifically target them?
  • What is the next generation of DCs modulators?

Japan-Flag   Korea-Flag   China-Simplified-Flag   China-Traditional-Flag