Breakfast Breakout Roundtable Discussions
WEDNESDAY, JUNE 19 | 8:00-8:55 AM
These are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic.
Modulation of Trained Immunity in Disease: from Bench to Bedside
Moderator: Mihai Netea, Radboud University Medical Center, Nijmegen, the Netherlands
- Trained immunity modulation: target diseases and approaches
- Pathophysiology of excessive inflammation: role of trained immunity
- Inhibitory strategies
- Targeting trained immunity and macrophage reprogramming in cancer
- Optimized myeloid cell-specific delivery
Clinical Development of CAR – NK Cells – Challenges and Opportunities
Moderator: Torsten Tonn, MD, PhD, Group Leader, Research Laboratory Experimental Transfusion Medicine; Professor, Transfusion Medicine, Medical Faculty Carl-Gustav-Carus, Technische Universität Dresden, Germany
- Relative resistance of NK cells to genetic manipulation (compared to T cells)
- How can we overcome the limitation in the in vitro and in vivo expansion capacity of NK cells
- How do the future CAR´s should look like for NK cell based therapies (inducible in vivo expansion, tonic signalling, universal CARs / CAR-PARK)
Targeting Dendritic Cells to Enhance T Cells Responses in Cancer
Moderator: Sonia Feau, PhD, Associate Director, Immunology, Oncorus
- Challenges and success of the different approaches: cell therapy, PAMPs agonists, vaccination
- How to specifically target them?
- What is the next generation of DCs modulators?